Frugarolo is a comune (municipality) in the Province of Alessandria in the Italian region Piedmont, located about 80 km southeast of Turin and about 11 km southeast of Alessandria. As of 31 December 2004, it had a population of 1,913 and an area of 27.3 km.

Frugarolo borders the following municipalities: Alessandria, Bosco Marengo, Casal Cermelli, and Castellazzo Bormida.